Potent oxindole based human beta3 adrenergic receptor agonists

F Craig Stevens; William E Bloomquist; Anthony G Borel; Marlene L Cohen; Christine A Droste; Mark L Heiman; Aidas Kriauciunas; Daniel J Sall; Frank C Tinsley; Cynthia D Jesudason

doi:10.1016/j.bmcl.2007.09.011

Potent oxindole based human beta3 adrenergic receptor agonists

Bioorg Med Chem Lett. 2007 Nov 15;17(22):6270-3. doi: 10.1016/j.bmcl.2007.09.011. Epub 2007 Sep 7.

Authors

F Craig Stevens¹, William E Bloomquist, Anthony G Borel, Marlene L Cohen, Christine A Droste, Mark L Heiman, Aidas Kriauciunas, Daniel J Sall, Frank C Tinsley, Cynthia D Jesudason

Affiliation

¹ Lilly Research Laboratories, Eli Lilly & Company, Lilly Corporate Center, Indianapolis, IN 46285, USA.

PMID: 17911024
DOI: 10.1016/j.bmcl.2007.09.011

Abstract

The synthesis and biological evaluation of a series of oxindole beta(3) adrenergic receptor agonists is described. A modulation of rat atrial tachycardia was observed with substitution at the 3-position of the oxindole moiety.

MeSH terms

Adrenergic beta-3 Receptor Agonists*
Adrenergic beta-Agonists / chemical synthesis*
Adrenergic beta-Agonists / chemistry
Adrenergic beta-Agonists / pharmacology*
Animals
CHO Cells
Cricetinae
Cricetulus
Disease Models, Animal
Drug Evaluation, Preclinical
Humans
Indoles / chemical synthesis*
Indoles / chemistry
Indoles / pharmacology*
Molecular Structure
Oxindoles
Rats
Rats, Long-Evans
Receptors, Adrenergic, beta-3 / biosynthesis
Receptors, Adrenergic, beta-3 / genetics
Tachycardia / drug therapy*

Substances

Adrenergic beta-3 Receptor Agonists
Adrenergic beta-Agonists
Indoles
Oxindoles
Receptors, Adrenergic, beta-3
2-oxindole